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Flouris et al., in a study on the short-term impact of active and passive use of nicotine-containing ECs versus conventional tobacco, found similar cotinine levels in users as in conventional tobacco smokers, with most changes occurring in smokers

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Plasma nicotine concentrations steadily increased during the one-hour ad lib use of the tobacco cigarettes, whereas ad lib use of the e-cigarettes resulted in plasma nicotine concentrations that increased during the first 45 min and then plateaued during the last 15 min

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